The Red Raiders outgained the Horned Frogs 211 yards to 133 in the first half, but Mayfield threw two interceptions, both in TCU territory, to keep Texas Tech from extending its lead.
TCU safety Chris Hackett intercepted Mayfield's pass at the Horned Frogs' 17 to end Texas Tech's second offensive series. In the second quarter, TCU cornerback Kevin White grabbed the ball away from Marquez at the Horned Frogs' 42.
Texas Tech also had a drive inside the TCU 20 foiled by penalties. Mayfield ran for 16 yards to the TCU 17 on a third-and-7 play, but the run was called back for a holding penalty, and the Red Raiders couldn't move back inside the TCU 40.
Meanwhile, TCU managed only six first downs in the first half and never crossed the Texas Tech 40.
NOTES: Texas Tech wore gray jerseys and gray helmets for the first time in school history. ... Texas Tech hosted a Thursday night game for the first time since 1994, when the Red Raiders lost to top-ranked Nebraska 42-16. ... TCU won its first-ever Big 12 opener last season, 20-6 at Kansas. ... The Horned Frogs entered the contest having won 16 of 17 conference road games.