CHICAGO -- Tampa Bay starter Jake Odorizzi struck out nine and allowed three hits in six shutout innings as the Rays beat the Chicago Cubs 4-0 on Saturday afternoon.

Odorizzi (8-9) walked none and allowed only one other baserunner on a hit by pitch.

Shortstop Yunel Escobar went 2-for-4 with an RBI and two runs scored and second baseman Ben Zobrist was 2-for-3 with two runs as the Rays (57-59) won their third in a row and second straight against the Cubs.

Chicago starter Edwin Jackson (6-12) took the loss as the Cubs (49-66) fell for the third time in four games.

The Rays opened a 1-0 lead in the fourth inning after Zobrist lined a shot into the right-field corner for a ground-rule double. He came home with one out on third baseman Evan Longoria's double to left. Escobar then lined an RBI single to right, scoring Longoria for a 2-0 lead.

Tampa Bay scored two runs in the sixth inning after Jackson loaded the bases with one out. Escobar's base hit up the middle on a 2-1 pitch scored Zobrist and Longoria for a 4-0 lead.

Jackson was pulled for a pinch hitter in the bottom of the sixth inning. He worked six innings and allowed four runs (three earned) and five hits while walking three and striking out three as he lost for the seventh time since June 9.

The Cubs threatened in the sixth inning when rookie second baseman Javier Baez doubled to deep left with two out but was stranded when first baseman Anthony Rizzo lined out to second.

Rays reliever Jake McGee allowed two base hits with two out in the ninth inning, but he stuck out Cubs third baseman Luis Valbuena to end the game.

The teams close out the three-game Wrigley Field series at 1:20 p.m. Sunday.

NOTES: Rays owner Stuart Sternberg said he had no regrets about the recent trade of ace LHP David Price. "It really was the classic one eye on the present, one eye on the future deal," Sternberg said. ... OF Kevin Kiermaier was the first Rays rookie since Evan Longoria in 2008 to deliver the winning RBI in an extra-inning game. Kiermaier had the winning 10th-inning single Friday. ... OF Wil Myers, on the disabled list since June 1 with a right wrist fracture, was scheduled to begin a rehab assignment Saturday at Triple-A Durham. ... The Rays send RHP Alex Cobb (7-6, 3.52 ERA) against Cubs LHP Travis Wood (7-9, 5.08 ERA) in Sunday's series finale. ... The Cubs are 5-8 this season in interleague play. They still have two series ahead against American League teams, including the Baltimore Orioles on Aug. 22-24 at home and a trip to Toronto on Sept. 8-10. The Rays are finished with interleague play after Sunday. ... Cubs 1B Anthony Rizzo went 1-for-4 and remains second in the National League home runs (25) and third in runs (75). He's also second in the NL in being hit by a pitch (12).